My picks:
- Denver (New Vegas sequel)
- LA or Chicago (Fallout 5)
- London (spin-off)
I think this will be handled by BGS (mainline 100%). Maybe Obsidian will return to it after Avowed is shipped (next year I would guess).
But that would bring some questions as assets made using the Creation Engine 2 don’t exist and I would suppose that this would be BGS’ task to make these and lead the art direction of next-gen Fallout (unless you can convert like from UE4 to UE5 but I think it’s unlikely).
But I also guess that pre-production of Fallout 5 will start after Starfield is shipped so it may not be a problem ultimately.