If this is true and Obsidian wanted to make a direct sequel to New Vegas, I think that Denver (Dog Town / the Cursed City, nearly broke the Legion) and Colorado just days after the death of Caesar reaches the place (trigerring civil war and the Hangdogs to declare war on the Legion) would be the perfect place.
There is potential to create something epic. NORAD and Cheyenne Mountain, Rocky Flats Plant, the Garden of the Gods, Vault 0… and we don’t know what are the exact factions beyond north and east of Denver.
